What is PLUTO?

Plasma-Lyte Usage and assessment of kidney Transplant Outcomes in children

PLUTO is a research study which aims to find out which fluid is best to give children and young people after a kidney transplant operation. This research will compare the ‘standard’ fluid used after the transplant operation with an alternative (called Plasma-Lyte), which may reduce abnormalities in salt (sodium) levels and help the transplant kidney to work better.

Why are we doing this?

The fluid used as ‘standard’ actually varies throughout the UK. Doctors use a combination of different strengths of saline (water mixed with salt), and a fluid called Hartmann’s (which also contains potassium and lactate). The alternative fluid is called Plasma-Lyte, which matches the normal composition of the blood more closely than the fluids which are being used currently. Although there are good reasons to believe that Plasma-Lyte may be a safer choice of fluid to use for a kidney transplant operation, there is not yet evidence which compares Plasma-Lyte with standard fluid for children and young people.

Information

for

patients

Info

for

patients

Under 6
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6 - 10 years
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11 - 15

years

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16 - 18

years

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Parents & Guardians
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Which hospitals are taking part in PLUTO?

Birmingham Children’s Hospital
Steelhouse Lane
Birmingham
B4 6NH

Principal Investigator: Dr Mordi Mourah

Bristol Royal Hospital for Children
Paul O’Gorman Building
Upper Maudlin Street
Bristol
BS2 8BJ

Principal Investigator: Dr Jan Dudley

Evelina London Children’s Hospital
St Thomas’ Hospital
Westminster Bridge Road
London
SE1 7EH

Principal Investigator: Dr Nick Ware

Royal Victoria Infirmary
Victoria Wing
Newcastle upon Tyne
NE1 4LP

Principal Investigator: Dr Michal Malina

Great Ormond Street Hospital
Great Ormond Street
London
WC1N 3JH

Principal Investigator: Dr Wesley Hayes

Leeds General Infirmary
Great George Street
Leeds
LS1 3EX

Principal Investigator: Dr Pallavi Yadav

Nottingham Children’s Hospital
Derby Road
Nottingham
NG7 2UH

Principal Investigator: Dr Martin Christian

Royal Belfast Hospital for Sick Children
274 Grosvenor Rd
Belfast
BT12 6BA

Principal Investigator: Dr Mairead Convery

Royal Manchester Children’s Hospital
Manchester Royal Infirmary
Oxford Road
Manchester
M13 9WL

Principal Investigator: Dr Mohan Shenoy

Meet the team

If you have any questions or queries about the study, please leave us a message below and we will be in touch with you shortly – The PLUTO Team